Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and activation (...) surges. BioEssays 30:542–555, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS‐CoV‐2 from a backbone of RaTG13‐like CoV and receptor binding domain (RBD) of a pangolin MP789‐like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS‐CoV‐2 (...) and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S‐protein gene sequences suggests that the RBD of SARS‐CoV‐2 probably represents an ancestral non‐recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS‐CoV‐2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. (shrink)

The causative agent of COVID‐19 SARS‐CoV‐2 has led to over 4 million deaths worldwide. Understanding the origin of this coronavirus is important for the prevention of future outbreaks. The dominant point of view that the virus transferred to humans either directly from bats or through an intermediate mammalian host has been challenged by Segreto and Deigin, who claim that the genome of SARS‐CoV‐2 has certain features suggestive of its artificial creation. Following their response to our commentary, here we continue the (...) discussion of the proposed arguments for this hypothesis. We show that neither the existence of a furin cleavage site in SARS‐CoV‐2, nor the presence of specific sequences within the nucleotide insertion encoding that site are evidence for intelligent design. We also explain why existing genetic data, viral diversity and past human history suggest that a natural origin of the virus is the most likely scenario. Genetic evidence suggesting otherwise is yet to be presented. (shrink)

States are rapidly modifying law and policy to increase access to the opioid antidote naloxone, and the provision of naloxone rescue kits for use in the event of overdose is becoming increasingly common. As of late 2014 the majority of states had passed laws increasing naloxone access, and nearly as many have modified emergency responder scope of practice protocols to permit Emergency Medical Technicians and law enforcement officers to administer the medication. While the text of these laws is generally similar, (...) their implementation varies among states.This article outlines experiences and lessons learned from two diverse states, Massachusetts and North Carolina. In Massachusetts naloxone access initiatives were well underway before formal legislative action occurred, while in North Carolina the passage of a naloxone access law served as a catalyst for the creation of new programs and facilitated the scale-up of existing ones. In both states legislative action was necessary to permit the prescription and dispensing of naloxone to the friends and family members of people who use opioids, a key legal change. (shrink)

Contemporary research highlights multiple societal and environmental benefits in addition to potential economic advantages associated with renewable energy utilization. As federal and state incentives for investments in RE technologies become more prevalent, RE sources represent increasingly viable alternatives to established fossil fuel energy. RE utilization is recognized as a key component of “green” product innovation that helps firms reduce the environmental impact of production processes and diminish their ecological footprints and energy consumption. Yet, despite consistent evidence that corporate sustainability initiatives (...) are favorably associated with firm performance, the limited research that examines associations between RE initiatives and firm performance yields mixed results and an explicit link has yet to be established. Drawing on the natural resource-based view of the firm, we examine the association between RE utilization and firm financial performance over time. Annual ROI, Tobin’s Q, and operating margin for large U.S. firms identified as exceptional users of RE in the EPA’s Fortune 500 Top Green Power Partners list are compared with their respective industry medians over a 7-year period and post hoc bootstrapping and sensitivity analyses are performed to further validate the study findings. Our research advances current knowledge about the influence of RE utilization by demonstrating that top RE user firms consistently generated superior financial performance compared to their industry competitors. As such, the study findings lend credence to the existence of a business case that complements the societal and environmental benefits of RE utilization. (shrink)

Explaining how stereotypes and norms influence role-identities during reflected appraisal processes, we develop a theory about diverse groups of minority men—the “minority masculinity stress theory”—and apply it to Asian American men. We conceptually integrate hegemonic masculinity, stereotypes, and mental health to examine how Asian American men experience masculinity and how their experiences are uniquely stressful. We analyze elicited text from an open-ended questionnaire to explain two experiences of masculinity-related stress: trying to live up to the masculine ideal and enacting work-related (...) role-identities. Regarding the former, we discuss four illustrations—toughness, body image, restrictive emotionality, and heterosexuality—and two involving the latter—achiever and provider. We found that Asian American men receive stereotypical reflected appraisals that contradict potentially positive self-concepts and emphasize achievement beyond typical standards of hegemonic masculinity. Moreover, Asian American men’s role-identities contradict hegemonic masculinity, resulting in reflected appraisals that predispose them toward stress. (shrink)

Most jurisdictions require that a mental capacity assessment be conducted using a functional model whose definition includes several abilities. In England and Wales and in increasing number of countries, the law requires a person be able to understand, to retain, to use or weigh relevant information and to communicate one’s decision. But interpreting and applying broad and vague criteria, such as the ability ‘to use or weigh’ to a diverse range of presentations is challenging. By examining actual court judgements of (...) capacity, we previously developed a descriptive typology of justifications used in the application of the Mental Capacity Act criteria. We here critically optimise this typology by showing how clear definitions—and thus boundaries—between the criteria can be achieved if the ‘understanding’ criterion is used narrowly and the multiple rationales that fall under the ability to ‘use or weigh’ are specifically enumerated in practice. Such a typology-aided practice, in theory, could make functional capacity assessments more transparent, accountable, reliable and valid. It may also help to create targeted supports for decision making by the vulnerable. We also discuss how the typology could evolve legally and scientifically, and how it lays the groundwork for clinical research on the abilities enumerated by the MCA. No data are available. This paper does not report any original data. (shrink)

Perceptual conscious experiences result from non-conscious processes that precede them. We document a new characteristic of the cognitive system: the speed with which visual meaningful stimuli are prioritized to consciousness over competing noise in visual masking paradigms. In ten experiments (N = 399) we find that an individual's non-conscious visual prioritization speed (NVPS) is ubiquitous across a wide variety of stimuli, and generalizes across visual masks, suppression tasks, and time. We also find that variation in NVPS is unique, in that (...) it cannot be explained by variation in general speed, perceptual decision thresholds, short-term visual memory, or three networks of attention (alerting, orienting and executive). Finally, we find that NVPS is correlated with subjective measures of sensitivity, as they are measured by the Highly Sensitive Person scale. We conclude by discussing the implications of variance in NVPS for understanding individual variance in behavior and the neural substrates of consciousness. (shrink)

This article reviews existing state laws related to autonomous vehicle (AV) safety, equity, and automobile insurance. Thirty states were identified with relevant legislation. Of these, most states had one or two relevant laws in place. Many of these laws were related to safety and insurance requirements. Data are needed to evaluate the effectiveness of these laws in order to guide further policy development.

The modern legal and ethical movement against traditional welfare paternalism in medical decision-making extends to how decisions are made for patients lacking decisional capacity, prioritising surrogates’ judgment about what patients would have decided over even their best interests. In England and Wales, the Mental Capacity Act 2005 follows this trend of prioritising the patient’s prior wishes, values and beliefs but the dominant interpretation in life-sustaining treatment cases does so by in effect calling those values the ‘best interests’ of the patient (...) and focusing nearly exclusively on the ‘subjective’ viewpoint of the patient. In this article, we examine the recent Court of Protection judgment inBarnsley Hospitals NHS Foundation Trust v MSP[2020] EWCOP 26, which adhered closely to this approach, to suggest that it could have unexpected negative consequences. These include insufficient information gathering about and attention to patients’ objective medical interests, inadequacy of the evidentiary standard used for the substituted decision-making and, in some cases, even prioritising a surrogate’s current substituted judgment over the potential for an actual judgment by the patient. (shrink)

All contemporary frameworks of mental capacity stipulate that we must begin from the presumption that an adult has capacity. This presumption is crucial, as it manifests respect for autonomy and guards against prejudice and paternalism on the part of the evaluator.Given its ubiquity, we might presume that we all understand the presumption’s meaning and application in the same way. Evidence demonstrates that this is not the case and that this has led to harm in vulnerable persons. There is thus strong (...) reason to question our presumptions about the presumption of capacity.We distinguish between two main ways of understanding and applying the presumption of capacity, and advocate for the one that we argue mitigates risk of harm. Our proposed interpretation offers many advantages in that it is consonant with actual practice of capacity evaluations, precludes confused and abusive avoidance of needed evaluations, and preserves the respect for autonomy motivating the presumption in the first place. (shrink)

The COVID-19 pandemic put a large burden on many healthcare systems, causing fears about resource scarcity and triage. Several COVID-19 guidelines included age as an explicit factor and practices of both triage and ‘anticipatory triage’ likely limited access to hospital care for elderly patients, especially those in care homes. To ensure the legitimacy of triage guidelines, which affect the public, it is important to engage the public’s moral intuitions. Our study aimed to explore general public views in the UK on (...) the role of age, and related factors like frailty and quality of life, in triage during the COVID-19 pandemic. We held online deliberative workshops with members of the general public. Participants were guided through a deliberative process to maximise eliciting informed and considered preferences. Participants generally accepted the need for triage but strongly rejected ‘fair innings’ and ‘life projects’ principles as justifications for age-based allocation. They were also wary of the ‘maximise life-years’ principle, preferring to maximise the number of lives rather than life years saved. Although they did not arrive at a unified recommendation of one principle, a concern for three core principles and values eventually emerged: equality, efficiency and vulnerability. While these remain difficult to fully respect at once, they captured a considered, multifaceted consensus: utilitarian considerations of efficiency should be tempered with a concern for equality and vulnerability. This ‘triad’ of ethical principles may be a useful structure to guide ethical deliberation as societies negotiate the conflicting ethical demands of triage. (shrink)

According to James Woodward’s influential interventionist account of causation, X is a cause of Y iff, roughly, there is a possible intervention on X that changes Y. Woodward requires that interventions be merely logically possible. I will argue for two claims against this modal character of interventions: First, merely logically possible interventions are dispensable for the semantic project of providing an account of the meaning of causal statements. If interventions are indeed dispensable, the interventionist theory collapses into a counterfactual theory (...) of causation. Thus, the interventionist theory is not tenable as a theory of causation in its own right. Second, if one maintains that merely logically possible interventions are indispensable, then interventions with this modal character lead to the fatal result that interventionist counterfactuals are evaluated inadequately. Consequently, interventionists offer an inadequate theory of causation. I suggest that if we are concerned with explicating causal concepts and stating the truth-conditions of causal claims we best get rid of Woodwardian interventions. (shrink)

Fregeans follow Frege in accepting informativeness and substitution failure as reliable criteria for the existence of senses as objects of thought. In this paper I show that if we accept this, we must also accept the existence of an infinite hierarchy of senses as objects of thought. This is a bad result since it turns Fregeanism into a doctrine according to which object-related thoughts either have an infinite number of objects as contents or none at all. This shows, against the (...) Fregean, that senses cannot themselves be constituents of thought. Los fregeanos aceptan, siguiendo a Frege, que los criterios de informatividad y falla de sustitución son guías confiables de la existencia de sentidos como objetos del pensamiento. En este artículo muestro que si aceptamos esta tesis también debemos aceptar la existencia de una jerarquía infinita de sentidos como objetos del pensamiento. Esta es una mala consecuencia pues convierte al fregeanismo en una doctrina según la cual los pensamientos dirigidos a objetos o bien tienen un número infinito de objetos como contenido o ninguno. Esto muestra, contra los fregeanos, que los sentidos no pueden ellos mismos ser objeto del pensamiento. (shrink)

La compasión es una actitud que ha sido objeto de ataques, que ha sido catalogada como un egoísmo encubierto o bien como una pose lastimera que poco o nada contribuye para el auxilio debido a las personas en desgracia. Pero, es precisamente el despojo y los daños que las personas sufren los que llevan a pensar cómo es posible «salvar» esas vidas, no permitir que se pierdan y afirmar que la vida vale la pena. En virtud de ello, la compasión (...) o misericordia ha de ser repensada con miras a concederle el lugar adecuado dentro del mundo sanitario. Su significado ético pasa, por tanto, por una elucidación racional –qué es- y los rasgos que la caracterizan –fragilidad, desgracia, reconocimiento, solidaridad-. El símbolo da que pensar, y la reflexión ética, en este caso, se nutre de la parábola del Buen Samaritano. (shrink)

Este artículo pretende generar claridades sobre el planteamiento sistémico, llevado a los universos de la escuela y la familia. Se plantean lugares de encuentro entre estos dos sistemas interconexionados por el pensamiento sistémico y la comunicación, rescatando que la escuela y la familia han sido determinantes en la configuración de subjetividades y sociedades. Estas reflexiones permiten concluir que las manifestaciones recíprocas de la familia y la escuela esculpen maneras de ser y de estar en el mundo.

This paper presents Bernard of Clairvaux as seen and interpreted by the Cistercian Abbot Isaac of Stella in his Sermon 52 In Assumptione Beatae Mariae. A comparison between the latter and Saint Bernard's sermon De tribus generibus emissionum (= De diversis 91) does not only reveal the important debt of Isaac to Bernard, but it also points to the innovative interpretation Isaac applies to Bernard's thought. Thus Isaac is shown to establish an original relation among ecclesiology, Mariology and a theology (...) of individual religious experience. (shrink)

El presente estudio busca clarificar el papel de la phantasia en la refundacion de la fenomenologia transcendental de Marc Richir (en particular desde Phenomenologie en esquisses, de 2000). A partir del analisis de la phantasia y de la imaginacion ��que toma apoyo en las Lecciones de Husserl de 1904/1905�� el autor pone de manifiesto la relacion de la phantasia tanto con la percepcion como con el lenguaje, al tiempo que trata de elucidar el estatuto temporal de dichos elementos.

This paper raises the question – based on the works of Marc Richir and Dominique Pradelle – if and how phenomenology deals with an “anti-Copernican” revolution, considering that the motif of a “Copernican” revolution seems to have gone through some modifications that reflect a certain deposition of the constitutive role of the subject. Its fundamental thesis is that a certain dimension “beyond” the Copernican revolution does not reestablish a “Ptolemaic” realism but rather opens a dimension “beneath”: beneath the subject and (...) the object where can take place a mutual relationship between an a-subjective constitutive power and a pre-empirical foundational being. This dimension “beneath” means that the alternative does not concern a “pre-Copernican” realism on the one hand and an “idealism” leaving in the shadows the relationship between the transcendental method and an ontological perspective on the other, but rather puts forward a constructive circularity between the transcendental constitution and an ontological foundation. It follows that “normativity” is not achieved on the basis of pre-given objectivity – because it would mean a petition principia – but draws upon the “pre-immanent generativity”. (shrink)

Casini, Illari, Russo, and Williamson (2011) suggest to model mechanisms by means of recursive Bayesian networks (RBNs) and Clarke, Leuridan, and Williamson (2014) extend their modelling approach to mechanisms featuring causal feedback. One of the main selling points of the RBN approach should be that it provides answers to questions concerning manipulation and control. In this paper I demonstrate that the method to compute the effects of interventions the authors mentioned endorse leads to absurd results under the additional assumption of (...) faithfulness, which can be expected to hold for many RBN models of mechanisms. (shrink)

The Mathematical Intelligencer recently published a note by Y. Sergeyev that challenges both mathematics and intelligence. We examine Sergeyev’s claims concerning his purported Infinity computer. We compare his grossone system with the classical Levi-Civita fields and with the hyperreal framework of A. Robinson, and analyze the related algorithmic issues inevitably arising in any genuine computer implementation. We show that Sergeyev’s grossone system is unnecessary and vague, and that whatever consistent subsystem could be salvaged is subsumed entirely within a stronger and (...) clearer system. Lou Kauffman, who published an article on a grossone, places it squarely outside the historical panorama of ideas dealing with infinity and infinitesimals. (shrink)

This article describes why I used to teach Introduction to Latin American Philosophy monolingually in English, why I stopped, and how I am now teaching it using a flexible bilingual pedagogy, also sometimes called a translanguaging pedagogy, that has been transformative for my students and for me. By drawing upon the ventajas/assets y conocimientos/knowledge of our richly varied bilingualisms and biliteracies, the revised course contributes to the B3 (bilingual, bicultural, and biliterate) vision of the University of Texas Rio Grande Valley (...) (UTRGV). Students have the opportunity to honor, theorize, and cultivate their bicultural identities by “philosophizing in tongues” rather than being forced to assimilate to the monolingual and monocultural ideology that prevails across both mainstream Anglophone philosophy and the system of higher education in the United States of America. (shrink)

Executive function is essential to child development, with associated skills beginning to emerge in the first few years of life and continuing to develop into adolescence and adulthood. The prefrontal cortex, which follows a neurodevelopmental timeline similar to EF, plays an important role in the development of EF. However, limited research has examined prefrontal function in young children due to limitations of currently available neuroimaging techniques such as functional resonance magnetic imaging. The current study developed and applied a multimodal Go/NoGo (...) task to examine the EF component of inhibitory control in children 4–10 years of age. Cortical activity was measured using a non-invasive and child-friendly neuroimaging technique – functional near-infrared spectroscopy. Children’s response accuracy and reaction times were captured during the fNIRS session and compared with responses obtained using the standardized assessments from NIH Toolbox cognition battery. Results showed significant correlations between the behavioral measures during the fNIRS session and the standardized EF assessments, in line with our expectations. Results from fNIRS measures demonstrated a significant, age-independent effect of inhibitory control in the right PFC, and an age-dependent effect in the left orbitofrontal cortex, consistent with results in previous studies using fNIRS and fMRI. Thus, the new task designed for fNIRS was suitable for examining IC in young children, and results showed that fNIRS measures can reveal prefrontal IC function. (shrink)

Hasdai Crescas (1340-1411) fue un filósofo, rabino y figura pública que vivió en un período muy turbulento para las comunidades judías ibéricas y provenzales de la Baja Edad Media. Crescas lanzó una crítica vehemente contra el paradigma aristotélico recibido de la _falsafa_, que fue utilizado por Maimónides para sustentar y probar la existencia, unidad e incorporeidad de Dios, conceptualizado en la _Guía de los perplejos_ como el ser necesario absolutamente trascendente en relación con el ser contingente, es decir, el mundo. (...) En _Or Hashem_, Crescas elabora un concepto alternativo del ser necesario, en el que las dos nociones antitéticas de inmanencia y trascendencia divinas se relacionan con la distinción en el ser necesario entre su esencia simple y sus atributos infinitos. La esencia simple, una e inefable del ser necesario, se expresa en infinitos atributos en el acto eterno y constante de otorgar en la univocidad del ser su bondad y su actualidad a los infinitos seres contingentes. Crescas defiende que el universo, aunque ontológicamente contingente, es infinito en su actualidad. Dios es así concebido como la primera causa, eterna y constante, entelequia y “Lugar del Mundo”. (shrink)

El presente artículo examina el concepto de necesidad causal y de contingencia en Roberto Kilwardby (ca. 1215-1279).Este autor, en su Comentario a los Segundos Analíticos de Aristóteles y en el De ortu scientiarum, parece particularmente interesado en el precario estatuto epistemológico de la ética y de la física en tanto que estas disciplinas versan sobre acontecimientos contingentes. Con el fin de reconciliar el conocimiento científico en sentido estricto con formas conjeturales de conocimiento, Kilwardby sitúa el problema de la contingencia en (...) un contexto auténticamente gnoseológico, más que metafísico, llegando así a una explicación altamente original de la contingencia. (shrink)